LBFM - Publications

Karst D. J., Steinebach F., Soos M. and M. Morbidelli, Process performance and product quality in an integrated continuous antibody production process, Biotechnology and Bioengineering 2017, 114, 298-307 Read article
Kroupa M., Soos M and J. Kosek, Slip on Particle Surface as the Possible Origin of Shear Thinning in non-Brownian Suspensions, Physical Chemistry Chemical Physics 2017, 19, 5979-5984 Read article
Sokolov M., Ritscher J., MacKinnon N., Bielser J.M., Bruhlmann D., Rothenhausler D., Thanei G., Soos M., Stettler M., Souquet J., Broly H., Morbidelli M. and A. Butte, Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody, Biotechnology Progress 2017, 33, 181-191 Read article
Jaquet B., Lazzari S., Colonna L., Colombo G., Soos M. and M. Morbidelli, Effects of Coalescence on Shear-Induced Gelation of Colloids, Langmuir 2017, 33, 1180-1188 Read article
Zvonicek V., skorepova E., Dusek M., Babor M., Zvatora P. and M. Soos, First Crystal Structures of Pharmaceutical Ibrutinib: Systematic Solvate Screening and Characterization, Crystal Growth & Design 2017, 17, 3116-3127 Read article
Karst D. J., Scibona E., Serra E., Bielser J. M., Settler M., Solacoup J., Broly H., Soos M., Morbidelli M. and T. K. Villiger, Modulation and modeling of monoclonal antibody N-linked glycosylation in mammalian cell perfusion reactors, Biotechnology and Bioengineering 2017, 117, 1978-1990
Saha D., Babler M.U., Holzner M., Soos M., Luthi B., Liberzon A. and W. Kinzelbach, Breakup of Finite-Size Colloidal Aggregates in Turbulent Flow Investigated by Three-Dimensional (3D) Particle Tracking Velocimetry, Langmuir 2016, 32, 55-65
Neunstocklin B., Villiger T. K., Lucas E., Stettler M., Broly H., Morbidelli M. and M. Soos, Pilot scale verification of maximum tolerable hydrodynamic stress for mammalian cell culture, Applied Microbiology and Biotechnology 2016, 100, 3489-3498
Steinhoff R., Karst D., Steinebach F., Kopp M., Schmidt G., Stettler A, Krismer J, Soos M., Pabst M., Hierlemann A., Morbidelli M. and R. Zenobi, Microarray-based MALDI-TOF mass spectrometry enables monitoring of monoclonal antibody production in batch and perfusion cell cultures, Methods 2016, 104, 33-40
Karst D. J., Serra E., Villiger T. K., Soos M. and M. Morbidelli, Characterization and comparison of ATF and TFF in stirred bioreactors for the continuous production of therapeutic proteins, Biochemical Engineering Journal 2016, 110, 17-26
Ullrich M., Hasa J., Hanus J., Soos M. and F. Stepanek, Perikinetic aggregation and stabilisation of cationic liposome clusters, Powder Technology 2016, 295, 115-121
Villiger T. K., Steinhoff R. F., Ivarsson M., Solacroup T., Stettler M., Broly H., Krismer J., Pabst M., Zenobi R., Morbidelli M. and M. Soos, High-throughput profiling of nucleotides and nucleotide sugars to evaluate their impact on antibody N-glycosylation, Journal of Biotechnology 2016, 229, 3-12
Vonka M., Storti G., Morbidelli M. and M. Soos, Viscosity and drop size evolution during suspension polymerization, AICHE Journal 2016, 62, 4229-4239
Kroupa M., Vonka M., Soos M. and J. Kosek, Utilizing the Discrete Element Method for the Modeling of Viscosity in Concentrated Suspensions, Langmuir 2016, 32, 8451-8460
Villiger T. K., Roulet A., Perilleux A., Stettler M., Broly H., Morbidelli M. and M. Soos, Controlling the time evolution of mAb N-linked glycosylation - Part I: Micro-bioreactor experiments, Biotechnology Progress 2016, 32, 1123-1134
Villiger T. K., Scibona E., Stettler M., Broly H., Morbidelli M. and M. Soos, Controlling the time evolution of mAb N-linked glycosylation - Part II: Model-based predictions, Biotechnology Progress, Biotechnology Progress 2016, 32, 1135-1148
Steinhoff R. F., Ivarsson M., Habicher T., Villiger T. K., Boertz J., Krismer J., Fagerer S., Soos M., Morbidelli M., Pabst M. and R. Zenobi, High-throughput nucleoside phosphate monitoring in mammalian cell fed-batch cultivation using quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, Biotechnology Journal 2015, 10, 190-198
Garcia Munzer D. G., Ivarsson M., Usaku C., Habicher T., Soos M., Morbidelli M., Pistikopoulos E. N. and A. Mantalaris, An Unstructured Model of Metabolic and Temperature Dependent Cell Cycle Arrest in Hybridoma Batch and Fed-Batch Cultures, Engineering Journal 2015, 93, 260-273
Ivarsson M., Noh H., Morbidelli M. and M. Soos, Insights into pH-induced Metabolic Switch by Flux Balance Analysis, Biotechnology Progress 2015, 31, 347-357
Villiger T. K., Morbidelli M. and M. Soos, Experimental determination of maximum effective hydrodynamic stress in multiphase flow using shear sensitive aggregates, AICHE Journal 2015, 61, 1735-1744
Neunstocklin B., Stettler M., Solacroup T., Broly H., Morbidelli M. and M. Soos, Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture, Journal of Biotechnology 2015, 194, 100-109
Vonka M. and M. Soos, Characterization of liquid-liquid dispersions with variable viscosity by coupled CFD with Population Balances, AICHE Journal 2015, 61, 2403-2414
Lamprou A., Gavriilidou A. F. M., Storti G., Soos M. and M. Morbidelli, Application of Polymeric Macroporous Supports for Temperature-Responsive Chromatography of Pharmaceuticals, Journal of Chromatography A 2015, 1407, 90-99
Kroupa M., Vonka M., Soos M. and J. Kosek, Size and Structure of Clusters Formed by Shear Induced Coagulation: Modeling by Discrete Element Method, Langmuir 2015, 31, 7727-7737
Hang I., Lin Ch., Grant O., Fleurkens S., Villiger T.K., Soos M., Morbidelli M., Woods R., Gauss R. and M. Aebi, Analysis of site-specific N-glycan remodelling in the ER and the Golgi, Glycobiology 2015, 25, 1335-1349
Sokolov M., Butte A., Soos M., Leardi R., Neunstocklin B., Solacroup T., Stettler M., Broly H., Morbidelli M., Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data, Biotechnology Progress 2015, 31, 1633-1644
Brand B., Morbidelli M. and M. Soos, Shear-Induced Reactive Gelation, Langmuir 2015, 31, 12727-12735
Codari F., Moscatelli D. S., Furlan M., Lattuada M., Morbidelli M and M. Soos, Synthesis of Hetero-Nano-Clusters: The Case of Polymer-Magnetite Systems, Langmuir 2014, 30, 2266-2273
Lamprou A., Kose I., Storti G., Morbidelli M. and M. Soos, Synthesis of Macroporous Polymer Particles using Reactive Gelation under Shear, Langmuir 2014, 30, 6946-6953
Ivarsson M., Villiger T. K., Morbidelli M. and M. Soos, Evaluating the Impact of Cell Culture Process Parameters on Monoclonal Antibody N-Glycosylation, Journal of Biotechnology 2014, 188, 88-96
Sieck J. B., Budach W. E., Suemeghy Z., Leist Ch., Villiger T. K., Morbidelli M. and M. Soos, Adaptation for Survival: Phenotype and Transcriptome Response of CHO Cells to Elevated Stress Induced by Agitation and Sparging, Journal of Biotechnology 2014, 189, 94-103
Lamprou A., Kose I., Pen?a Z. A., Storti G., Morbidelli M. and M. Soos, Macroporous Polymer Particles via Reactive Gelation under Shear: Effect of Primary Particle Properties and Operating Parameters, Langmuir 2014, 30, 13970-13978
Saha D., Soos M., Luthi B., Holzner M., Liberzon A., Babler M. U. and W. Kinzelbach, Experimental characterization of breakage rate of colloidal aggregates in axisymmetric extensional flow, Langmuir 2014, 30, 14385-14395
de Neuville B. C., Lamprou A., Morbidelli M. and M Soos, Perfusive ion-exchange chromatographic materials with high capacity, Journal of Chromatography A 2014, 1374, 180-188
Sieck J. B., Cordes T., Budach W. E., Rhiel M. H., Suemeghy Z., Leist Ch., Villiger T. K., Morbidelli M. and M. Soos, Development of a scale-down model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions, Journal of Biotechnology 2013, 164, 41-19
Soos M., Marchisio D. L. and J. Sefcik, Assessment of gel formation in colloidal dispersions during mixing in turbulent jets, AICHE Journal 2013, 59, 4567-4581
Soos M., Kaufmann R., Winteler R., Kroupa M. and B. Luthi, Determination of Maximum Turbulent Energy Dissipation Rate generated by a Rushton Impeller through Large Eddy Simulation, AICHE Journal 2013, 59, 3642-3658
Lazzari S., Maggioni G. M., Soos M., Wu H. and M. Morbidelli, Shear-Stability and Gelation of Inverse Latexes, Soft Matter 2013, 9, 10866-10876
Moussa A. S., Lattuada M., Conchuir B.O., Zaccone A., Morbidelli M. and M. Soos, Flow-Induced Aggregation and Breakup of Particle Clusters Controlled by Surface Nanoroughness, Langmuir 2013, 29, 14386-14395
Codari F., Lazzari S., Soos M., Storti G., Morbidelli M. and D. Moscatelli, Kinetics of the hydrolytic degradation of poly(lactic acid), Polymer Degradation and Stability 2012, 97, 2460-2466
Sorg R., Tanzeglock T., Soos M., Morbidelli M., Perilleux A., Solacroup T. and H. Broly, Minimizing hydrodynamic stress in mammalian cell culture through the lobed Taylor-Couette bioreactor, Biotechnology Journal 2011, 6, 1504-1515
Harshe Y., Lattuada M. and M. Soos, Experimental and modeling study of breakage and restructuring of open and dense colloidal aggregates, Langmuir 2011, 27, 5739-5752
Trtik P., Soos M., Muench B., Lamprou A., Mokso R. and M. Stampanoni, Quantification of a single aggregate inner porosity and pore accessibility using hard X-ray Phase-Contrast Nanotomography, Langmuir 2011, 27, 12788-12791
Soos M., Ehrl L., Babler M. U. and M. Morbidelli, Aggregate breakup in a contracting nozzle, Langmuir 2010, 26, 10-18
Ehrl L., Soos M., Wu H. and M. Morbidelli, Effect of flow field heterogeneity in coagulators on aggregate size and structure, AICHE Journal 2010, 56, 2573-2587
Babler M. U., Moussa A. S., Soos M. and M. Morbidelli, Structure and kinetics of shear aggregation in turbulent flows. I. Early stage of aggregation, Langmuir 2010, 26, 13142-13152
Ehrl L., Jia Z., Wu H., Lattuada M., Soos M. and M. Morbidelli, Role of counterion association in colloidal stability, Langmuir 2009, 25, 2696-2702
Ehrl L., Soos M. and M. Morbidelli, Dependence of initial cluster aggregation kinetics on shear rate for particles of different sizes under turbulence, AICHE Journal 2009, 55, 3076-3087
Tanzeglock T., Soos M. and M. Morbidelli, Prediction of cell damage in stirred bioreactors-from small-scale model systems to a novel bioreactor design, New Biotechnology 2009, 25, S190-S191
Tanzeglock T., Soos M., Stephanopoulos G. and M. Morbidelli, Induction of mammalian cell death by simple shear and extensional flows, Biotechnology and Bioengineering 2009, 104, 360-370
Zaccone A., Soos M., Lattuada M., Wu H. and M. Morbidelli, Breakup of dense colloidal aggregates under hydrodynamic stresses, Physical Review E. 2009, 79, 061401
Ehrl L., Soos M. and Lattuada M., Generation and geometrical analysis of dense clusters with variable fractal dimension, Journal of Physical Chemistry B 2009, 113, 10587-10599
Soos M., Lattuada M. and J. Sefcik, Interpretation of light scattering and turbidity measurements in aggregated systems: Effect of Multiple-Light Scattering, Journal of Physical Chemistry B 2009, 113, 14962-14970
Soos M., Moussa A. S., Ehrl L., Sefcik J., Wu H. and M. Morbidellis, Effect of shear rate on aggregates size and morphology investigated under turbulent conditions in stirred tank, Journal of Colloid Interface Science 2008, 319, 577-589
Ehrl L., Soos M. and M. Morbidelli, Dependence of aggregate strength, structure, and light scattering properties on primary particle size under turbulent conditions in stirred tank, Langmuir 2008, 24, 3070-3081
Soos M., Moussa A. S., Ehrl L., Sefcik J., Wu H. and M. Morbidelli, Dynamic response studies on aggregation and breakage dynamics of colloidal dispersions in stirred tanks, Journal of Dispersion Science and Technology 2008, 29, 605-610
Ehrl L., Soos M. and M. Morbidelli, Sizing polydisperse dispersions by focused beam reflectance and small angle static light scattering, Particle & Particle System Characterization 2007, 23, 438-447
Soos M. Wu H. and M. Morbidelli, Taylor-Couette unit with a lobed inner cylinder cross section, AIChE Journal 2007, 53, 1109-1120
Soos M., Rajniak P. and F. Stepanek, Percolation models of adsorption-desorption equilibria and kinetics for systems with hysteresis, Colloids and Surfaces A. 2007, 300, 191-203
Stepanek F., Soos M. and P. Rajniak, Characterization of porous media by the virtual capillary condensation method, Colloids and Surfaces A. 2007, 300, 11-22
Moussa A., Soos M., Sefcik J. and M. Morbidelli, Effect of the solid volume fraction on aggregation and breakage of colloidal suspensions in batch and continuous stirred tanks, Langmuir 2007, 23, 1664-1673
Soos M., Sefcik J. and M. Morbidelli, Master curves for aggregation and gelation: Effects of cluster structure and polydispersity, Industrial & Engineering Chemistry Research 2007, 46, 1709-1720
Soos M., Wang L., Fox R.O., Sefcik J. and M. Morbidelli, Population balance modeling of aggregation and breakage in turbulent Taylor-Couette flow, Journal of Colloid Interface Science 2007, 307, 433-446
Marchisio D. L., Soos M., Sefcik J and M. Morbidelli, Role of turbulent shear rate distribution in aggregation and breakage processes, AIChE Journal 2006, 52, 158-173
Marchisio D. L., Soos M., Sefcik J., Morbidelli M., Barresi A. A. and G. Baldi, Effect of fluid dynamics on particle size distribution in particulate processes, Chemical Engineering and Technology 2006, 29, 191-199
Soos M, Sefcik J and M. Morbidelli, Investigation of aggregation, breakage and restructuring kinetics of colloidal dispersions in turbulent flows by population balance modeling and static light scattering, Chemical Engineering Science 2006, 61, 2349-2363
Sefcik J., Soos M., Vaccaro A. and M. Morbidelli, Effects of mixing on aggregation and gelation of nanoparticles, Chemical Engineering and Processing 2006, 45, 936-943
Waldner M. H., Sefcik J., Soos M. and M. Morbidelli, Initial growth kinetics of aggregates in turbulent coagulator, Powder Technology 2005, 156, 226-234
Soos M., Graczova E, Markos J., Molnar A. and P. Steltenpohl, Design and simulation of a distillation column for separation of dichloropropane from a multicomponent mixture, Chemical Engineering and Processing 2003, 42, 273-284
Soos M. and P. Rajniak, Percolation models of adsorption-desorption kinetics with hysteresis, Chemical Papers 2002, 56, 62-69
Smejkal Q. and M. Soos, Comparison of computer simulation of reactive distillation using ASPEN PLUS and HYSYS software, Chemical Engineering and Processing 2002, 41, 413-418
Markos J., Soos M. and L. Jelemensky, Design and simulation of a reactor for the chlorination of acetone in gaseous phase, Chemical Engineering Science 2001, 56, 627-632
Soos M. and P. Rajniak, Percolation model of adsorption-desorption equilibria with hysteresis, Chemical Papers 2001, 55, 391-396
Soos M., Rajniak P. and R. Zajdlik, Mathematical and experimental modelling of sorption processes in a fixed bed adsorber, Chemical Papers 2000, 54, 489-495
Stepanek F., Kubicek M., Marek M., Soos M., Rajniak P, and R. T. Yang, On the modeling of PSA cycles with hysteresis-dependent isotherms, Chemical Engineering Science 2000, 55, 431-440
Markos J., Jelemensky L, Soos M. and V. Camaj, Selective chlorination of acetone in the gas phase, Industrial & Engineering Chemistry Research 1999, 53, 349-346
Rajniak P., Soos M. and R.T. Yang, Unified network model for adsorption-desorption in systems with hysteresis, AIChE Journal 1999, 45, 735-750

Nanoparticles synthesis

CFD modelling

Particle assembly in the flow

Recent publications

Books and contributions to books

Patents